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Sermorelin Therapy

Woman running in parkHow does Sermorelin work?

Sermorelin works to stimulate the pituitary gland to produce and secrete hGH. Natural hGH peaks at age 20. Beginning at age 30, humans experience a 14% reduction in hGH every decade of life. By age 40, the production of the human growth hormone is only 40% of what it was at 20. It is possible to stimulate the pituitary gland to produce hGH again, even after this decline in production has occurred, by using Growth Hormone Releasing Factor (GRF).

What to expect

Week 1 – Improved quality of sleep

Week 2 – Recovery from workouts

Week 4 – Mental Clarity

Week 6 – Skin elasticity improved

Week 8 – Body Composition

*Patients may stay on Sermorelin indefinitely or they may come off therapy to take a break from daily injections.

Benefits of Sermorelin

You may want to know how you can benefit from using this therapy. Perhaps the easiest way to understand the potential benefits of hGH replacement therapy is to look at the symptoms of hGH decline and the effect hGH replacement has on these symptoms. These are detailed below:

Changes in Body Composition

Changes in body composition due to decreasing levels of hGH are reflected by a decrease in lean body mass (muscle) and an increase in fat mass. Correcting hGH levels has been shown to reverse this state by improving muscle mass and reducing fat.

Bone Mineral Density

Research indicates that hGH deficiency in adults contributes to a reduction in bone density and therefore increased the risk of osteoporosis. It has also been shown that hGH replacement therapy for greater than 12 months results in improved bone mineral density and hence, lower risk of osteoporosis.

Joint Health

By improving bone mineral density and increasing muscle mass and strength, hGH therapy can help to prevent joint deterioration that is a feature of arthritis. Optimal growth hormone levels are also essential for the health of connective tissue such as the synovium found in joints.

Exercise Performance

Exercise performance is reduced in individuals with growth hormone deficiency. This appears to be partially due to a reduction in bone density and muscle mass but also in part due to a reduction in oxygen uptake. hGH therapy for six months has been shown to increase exercise performance by improving muscle mass and also oxygen uptake.

Heart Health

There is evidence of a greater risk of heart disease in individuals with growth hormone deficiency and it has been hypothesized that this is due to a greater propensity develop premature atherosclerosis (a buildup of plaque inside the arteries which increases the risk of heart attack and stroke). Growth hormone deficiency also results in changes in heart size and function. These changes have been demonstrated to be reversed after six months of hGH therapy.


Growth hormone deficiency results in a reduced resting metabolism and replacement therapy reverses this decrease. hGH therapy has also been shown to increase protein synthesis, increase fat oxidation, normalize carbohydrate metabolism and reduce LDL (bad cholesterol). These favorable effects on metabolism may in part explain some of the other benefits of hGH including improved heart health and body composition.

Skin Thickness

A reduction in skin thickness and all-important skin collagen is another result of growth hormone deficiency. Both conditions are improved by hGH therapy.

Immune Function

Although adults with growth hormone deficiency are not normally considered to have a compromised immune system, there is some evidence to suggest that hGH therapy can help regulate immune function.


It has been demonstrated that people with growth hormone deficiency have more difficulty with sexual relationships and reportedly, lower energy levels. Many individuals have found an improvement in energy, libido and sexual performance following hGH therapy, some men even claiming an improvement in problems with premature ejaculation.

Quality of Life

Reduced psychological well-being has been reported in individuals with growth hormone deficiency and hGH replacement has resulted in improvements in mood, energy and general feelings of well-being.